Which statement best describes how a new human trait develops and can be passed

Which statement best describes how a new human trait develops and can be passed on to future generations?
A mutation in a stomach cell results in the inability of a woman to produce a certain digestive enzyme
2.
A mother consumes alcohol during pregnancy, causing the fetus to have a low birth weight
During meiosis, a new combination of DNA subunits is formed.
4.
During mitosis, DNA does not divide correctly and the cells die.